Virtual Institute on Poverty Related Diseases

3 October 2016

Division of AIDS Research (DAR) has joined the EURIPRED EXTRANET

The Division of AIDS Research (DAR) supports research to reduce the incidence of HIV/AIDS worldwide and to decrease the burden of living with HIV/AIDS. DAR-supported research encompasses a broad range of studies that includes basic and clinical neuroscience of HIV infection to understand and alleviate the consequences of HIV infection of the central nervous system (CNS), and basic and applied behavioral science to prevent new HIV infections and limit morbidity and mortality among those infected. DAR places a high priority on interdisciplinary research across multiple populations, including racial and ethnic minorities, over the lifespan.

The portfolio on the basic neuroscience of HIV infection includes research to: elucidate the mechanisms underlying HIV-induced CNS dysfunction in the setting of long-term antiretroviral therapy; understand the motor, cognitive, and behavioral impairments that result from HIV infection of the CNS; develop novel treatments to prevent or mitigate the CNS complications of HIV infection; and, minimize the neurotoxicity induced by long-term use of antiretroviral therapy. Critical approaches to this effort require molecular, cellular, and genetic studies to delineate the pathophysiologic mechanisms that lead to HIV induced CNS dysfunction, and to identify potential targets for therapeutic intervention. In addition, eradication of the virus from HIV-infected individuals to achieve a cure or a functional cure is a high priority.